Hauv kev sib tw toj roob hauv pes ntawm kev tsim tshuaj, qhov zoo ntawm qhov kawg hollow capsule yog inextricably txuas rau qhov zoo ntawm nws cov ntaub ntawv raw. Txawm hais tias muaj ntau qhov kev saib xyuas feem ntau tau them rau cov molding thiab ziab ntu ntawm cov kab ntau lawm, "tus neeg uas ntsiag to" ntawm cov txheej txheem - lub tshuab gelatin sib xyaw thiab melting system- tab tom muaj kev hloov pauv tseem ceeb. Rau cov tuam txhab tshuaj ntsiav tsom rau kev ua raws li GMP thiab cov viscosity zoo ib yam, kev hloov kho mus rau tom ntej - tiam cov chav sib xyaw yog tsis xaiv ntxiv lawm; nws yog qhov tsim nyog.
Qhov Kev Sib Tw ntawm Viscosity thiab Consistency
Kev tsim cov qib siab - zoo gelatin tov yuav tsum tau tswj xyuas qhov kub, siab, thiab sib tov ceev. Cov ntawv qhia ib txwm siv lossis ib nrab- cov twj tso kua mis sib xyaw ua ke feem ntau raug kev txom nyem los ntawm cov cua sov tsis sib xws, ua rau "qhov kub" uas tuaj yeem ua rau cov gelatin protein ntau dua. Tsis tas li ntawd, kev taw qhia ntawm cov pa npuas thaum lub sij hawm sib xyaw ua ke tuaj yeem ua rau muaj qhov tsis muaj zog nyob rau hauv lub plhaub capsule kawg, ua rau brittleness los yog to.
Niaj hnub nimno automated systems tab tom hais txog cov ntsiab lus mob no los ntawm kev tshaj lij engineering. Cov tiam tshiab ntawm gelatin melting tanks tam sim no nta peb npaug - txheej rwb thaiv tsev thiab roj- lub tshuab cua sov. Tsis zoo li qub chav - cov qauv cua sov, cov roj- cov tshuab hluav taws xob muab cov hluav taws kub sib txawv uas tiv thaiv cov cua sov hauv cheeb tsam. Qhov no ua kom cov gelatin tswj nws cov molecular kev ncaj ncees, ua rau lub plhaub capsule nrog superior txhua yam muaj zog.
Nqus De- aeration: Kev hloov kho tshiab tseem ceeb
Ib qho kev nce qib tseem ceeb tshaj plaws hauv kev tsim khoom tsis ntev los no (txhawb nqa) cov tshuab yog kev sib koom ua ke ntawm lub tshuab nqus tsev de- aeration ncaj qha mus rau theem sib xyaw. Yav dhau los, de- aeration feem ntau yog cais, lub sij hawm-siv kauj ruam. Niaj hnub no cov kev sib xyaw ua ke siv siab - lub tshuab nqus tsev twj tso kua mis kom txo qhov siab hauv lub tank sib tov kom ze rau - qib xoom.
Cov txheej txheem no yuam kom yaj cov huab cua thiab cov npuas nkag mus rau saum npoo thiab khiav ua ntej cov gelatin tau muab tso rau hauv lub tank dipping. Qhov tshwm sim yog crystal- ntshiab, npuas - dawb gelatin tov. Rau cov tuam txhab tsim khoom siab - cov tshuaj capsules meej lossis cov uas xav tau cov xim sib xws, cov kauj ruam no tsis yog - sib tham. Los ntawm kev tshem tawm cov huab cua, cov tuam ntxhab kuj txo qhov kev pheej hmoo ntawm oxidation, ncua lub txee lub neej ntawm cov tshuaj npaj.
Smart Control thiab CIP kev koom ua ke
Kev lag luam 4.0 kiv puag ncig tau mus txog cov khoom siv raw khoom npaj. Cov txheej txheem sib xyaw tshiab tau nruab nrog PLC (Programmable Logic Controller) interfaces uas tso cai rau cov tswv lag luam kom txuag tau cov "daim ntawv qhia" tshwj xeeb rau ntau hom gelatin (piv txwv li, Bloom zog variations). Lub kaw lus tau hloov kho qhov nrawm nrawm thiab cua sov nkhaus raws li daim ntawv qhia xaiv.
Tsis tas li ntawd, kev nyiam huv yog qhov tseem ceeb. Cov chav nyob tshiab dhau los ua tus qauv nrog CIP (Tshwj xeeb-Hauv-Place) cov pob tshuaj tsuag thiab tig lub taub hau ntxuav. Cov cuab yeej no xyuas kom meej tias txhua nti ntawm lub tank sab hauv thiab cov kav dej yog huv si yam tsis tas yuav tsum tau siv phau ntawv disassembly. Qhov no tsis yog tsuas yog txo cov nqi ua haujlwm xwb tab sis kuj txo qis qhov kev pheej hmoo ntawm kev hla -kev sib kis ntawm cov khoom siv, qhov tseem ceeb tshaj plaws rau FDA thiab EMA kev tshuaj xyuas.
Raws li qhov kev thov rau cov tshuaj ntsiav tshuaj loj tuaj, lub siab los txhim kho cov txheej txheem sab saud intensifies. Kev nqis peev nyob rau hauv ib qho kev ua haujlwm siab tshaj plaws gelatin mixing system yog kev nqis peev hauv lub hauv paus ntawm cov khoom. Los ntawm kev ua kom muaj kev sib haum xeeb, tshem tawm cov npuas, thiab kev ua haujlwm ntawm kev nyiam huv, cov tuam txhab lag luam tuaj yeem txo qis kev tsis lees paub hauv qhov kev tshuaj ntsuam zaum kawg, ua pov thawj tias txoj kev mus rau qhov zoo tshaj plaws capsule pib ntev ua ntej cov txheej txheem dipping.